Rabies Immune Globulin, (RIG), Human

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Rabies Immune Globulin, (RIG), Human

  Action
  Indications
  Contraindications
  Route/Dosage
  Interactions
  Lab Test Interferences
  Adverse Reactions
  Precautions
Patient Care Considerations
  Administration/Storage
  Assessment/Interventions
  Patient/Family Education


(RAY-beez ih-MYOON GLAB-byoolin)
Hyperab, Imogam
Class: Immune serum

 Action Directly neutralizes rabies virus.

 Indications Passive, transient postexposure prevention of rabies infection in susceptible individuals.

 Contraindications Repeated doses once vaccine treatment has been initiated. RIG may theoretically be contraindicated in persons who have had life-threatening reactions to human IgG antibody products or any RIG components. Previous complete immunization with rabies vaccine and presence of adequate antibody titer.

 Route/Dosage

ADULTS & CHILDREN: IM 20 IU/kg (0.133 ml/kg) as soon as possible after exposure, preferably with first dose of vaccine.

 Interactions

Measles, mumps, polio, or rubella live vaccines: Other antibodies in RIG preparation may interfere with response to these live vaccines.

 Lab Test Interferences None well documented.

 Adverse Reactions

DERM: Urticaria; skin rash. GU: Nephrotic syndrome. OTHER: Local tenderness, soreness, or stiffness at injection site; low-grade fever; angioedema; sensitization to repeated injections; anaphylactic shock.

 Precautions

Pregnancy: Category C. Use only if clearly needed. Lactation: Unknown. Hypersensitivity to thimerosal or human immunoglobulins: Give drug with caution. Live vaccines: To avoid inactivating live vaccines, do not give live vaccines within 4 mo after RIG.


PATIENT CARE CONSIDERATIONS


 Administration/Storage

 Assessment/Interventions

 Patient/Family Education

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Copyright
© 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts